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Custom formulated with up to 4 rx-only active ingredients azelaic acid, tretinoin, clindamycin, niacinamide, and metronidazole.

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Information about Tretinoin.

Wash your hands before and after applying tretinoin topicalBefore applyingclean and dry the skin area to be treated.

GELS ARE FLAMMABLENoteKeep away from heat and flameKeep tube tightly closed.

Tretinoin comes in topical liquidcreamand gelTretinoin usually is used daily at bedtime or once every 2 or 3 daysFollow the directions on your prescription label carefullyand ask your doctor or pharmacist to explain any part you do not understandUse tretinoin exactly as directedDo not use more or less of it or use it more often than prescribed by your doctor.

Seek emergency medical attention if you think you have used too much of this medicineTretinoin topical is not expected to cause overdose symptoms.

Use it regularly in order to get the most benefit from itTo help you rememberuse it at the same time each dayDo not use a larger amount or use it more frequently than recommendedYour skin will not improve any fasterand it will increase the risk of developing rednesspeeling and pain.

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although tretinoin activates three members of the retinoic acid rar nuclear receptors rar , rar , and rar which may act to modify gene expression, subsequent protein synthesis, and epithelial cell growth and differentiation, it has not been established whether the clinical effects of tretinoin are mediated through activation of retinoic acid receptors and or other mechanisms.